Abstract
A series of imidazole derivatives has been prepared using high throughput parallel synthesis. Several compounds showed high affinity (Ki in 10(-6)-10(-8) M range) and selectivity at recombinant human somatostatin receptor subtype 3 (hsst3).
MeSH terms
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Amides / chemical synthesis
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Amides / pharmacology*
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Animals
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Binding Sites / physiology
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CHO Cells
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Colforsin / pharmacology*
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Cricetinae
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Cyclic AMP / agonists*
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Cyclic AMP / analysis
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Cyclic AMP / biosynthesis
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Dose-Response Relationship, Drug
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Humans
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Imidazoles / chemical synthesis
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Imidazoles / pharmacology
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Ligands
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Nitrobenzenes / chemical synthesis
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Nitrobenzenes / pharmacology*
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Protein Binding / physiology
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Receptors, Somatostatin / antagonists & inhibitors*
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Recombinant Proteins / antagonists & inhibitors
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Somatostatin / pharmacology*
Substances
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Amides
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Imidazoles
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L796778
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Ligands
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Nitrobenzenes
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Receptors, Somatostatin
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Recombinant Proteins
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somatostatin receptor 3
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Colforsin
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Somatostatin
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Cyclic AMP